MDL Snapshot AML Pnl (AMS)
Department: Molecular Diagnostics
Test Synonym(s): LAB5781, AMS, AML SNaPshot
CPT Codes: 81120, 81121, 81246
Methodology: Multiplex PCR/Multiplex base extension using the ABI SNaPshotTM methodology; Laboratory Developed Test
Tube Type: Lavender top (EDTA)
Specimen: Blood, bone marrow, purified DNA - 1 microgram (NOTE: refer to Reasons for Rejection for DNA extraction criteria)
Alternate Specimen: Yellow top (ACD-A) for whole blood or bone marrow
Volume: 1 tube
Minimum Volume: 2 microtainers blood or bone marrow
Temperature: Refrigerated or room temperature
Stability: Room Temperature - 2 days, Refrigerated - 7 days
Reasons for Rejection: Client will be notified by Molecular Diagnostics Lab if specimen is rejected. Purified DNA - externally extracted nucleic acid received for clinical testing only accepted from CLIA-certified laboratories or laboratories meeting equivalent requirements as determined by College of American Pathologists (CAP) and/or CMS. Documentation stating that the DNA was extracted in a CLIA lab will be required and should accompany the DNA specimen. DNA samples received from facilities not meeting requirements will be rejected. The Molecular Diagnostic Laboratory medical director will contact the referral facility.
Days Performed: Monday and Thursday
Times Performed: Batched
TAT: Dependent upon date of receipt
Significance: Identification of 18 common Variants in IDH1/2 and 20 common FLT3-TKD variants Associated with Acute Myeloid Leukemia
Special Instructions: Call or email the Molecular Diagnostics Laboratory at 615-343-8121 or moleculardiagnosticlab@vumc.org if assistance is needed for specimen submission or if the patient has received a transfusion in the prior 2 weeks or has a history of a stem cell transplant.
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